Through her music and other art forms, Mai Khoi brings to the forefront the importance of freedom of expression, social justice and improving the human rights situation in Vietnam. In her life and work, she emphasizes the right of everyone to make their own choices. Themes that Mai Khoi draws attention to include equal opportunities for women and the LGBTI+ community, gender-based violence, freedom of expression, and the environment. Among other things, she called attention to the poison disaster in Formosa in 2016 that caused environmental damage and had a major economic impact on local fishers. She also contributed to "The Bamboo Talk," a play about caring (for each other and nature) and sharing water, food and friendship. These things, according to Mai Khoi, are essential for a sustainable inclusive society.